Yan Long Selected Research

leukotriene D4 receptor (cysteinyl leukotriene receptor)

11/2021	CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice.
10/2021	Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice.
4/2017	Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice.
1/2017	CysLT1R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice.
12/2016	Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice.
5/2016	Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice.
9/2014	Montelukast rescues primary neurons against Aβ1-42-induced toxicity through inhibiting CysLT1R-mediated NF-κB signaling.
4/2014	Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice.

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Yan Long Research Topics

Disease

18	Neoplasms (Cancer) 02/2022 - 05/2012
17	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 02/2013
16	Neuroinflammatory Diseases 01/2022 - 02/2013
15	Cognitive Dysfunction 01/2022 - 12/2002
10	Inflammation (Inflammations) 08/2022 - 09/2016
9	Memory Disorders (Memory Loss) 07/2022 - 02/2013
7	Pre-Eclampsia (Preeclampsia) 01/2022 - 01/2016
6	Infections 01/2022 - 01/2017
6	Starvation 11/2020 - 01/2015
5	Asthma (Bronchial Asthma) 07/2017 - 04/2014
4	Insulin Resistance 04/2019 - 06/2009
4	Shock 01/2017 - 04/2014
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2022 - 01/2018
3	Colitis 05/2022 - 10/2008
3	Lymphoma (Lymphomas) 01/2022 - 04/2012
3	Type 2 Diabetes Mellitus (MODY) 01/2022 - 08/2012
3	Prostatic Neoplasms (Prostate Cancer) 04/2021 - 09/2018
3	Hyperglycemia 01/2017 - 08/2012
3	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2005 - 03/2002
2	Carcinoma (Carcinomatosis) 05/2022 - 10/2021
2	Body Weight (Weight, Body) 05/2022 - 08/2012
2	Chronic Hepatitis B 01/2022 - 11/2021
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 01/2021
2	Cicatrix (Scar) 01/2022 - 12/2014
2	Autoimmune Diseases (Autoimmune Disease) 11/2021 - 01/2021
2	Amyloidosis 11/2021 - 01/2014
2	Gestational Diabetes (Gestational Diabetes Mellitus) 11/2020 - 01/2015
2	Inborn Errors Metabolism (Inborn Errors of Metabolism) 04/2020 - 01/2019
2	Type A Niemann-Pick Disease 01/2019 - 12/2016
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2018 - 01/2018
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 05/2017 - 12/2016
2	Hyperlipidemias (Hyperlipidemia) 01/2017 - 08/2012
2	Ulcerative Colitis 09/2016 - 10/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2015 - 05/2005

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 07/2022 - 09/2003
13	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2013
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
8	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 11/2021 - 04/2014
7	Streptozocin (Streptozotocin)FDA Link 01/2022 - 08/2012
7	Arginine (L-Arginine)FDA Link 02/2020 - 05/2012
6	EnzymesIBA 10/2022 - 05/2012
6	Circular RNAIBA 07/2022 - 01/2018
5	AcidsIBA 05/2022 - 10/2008
5	Peptides (Polypeptides)IBA 01/2022 - 02/2013
5	Caspase 3 (Caspase-3)IBA 04/2021 - 04/2014
5	LipopolysaccharidesIBA 06/2020 - 01/2018
5	Pharmaceutical PreparationsIBA 09/2018 - 05/2005
4	CytokinesIBA 12/2020 - 04/2014
4	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 02/2020 - 05/2012
4	Insulin (Novolin)FDA Link 04/2019 - 06/2009
4	ADI PEG20IBA 01/2017 - 05/2012
3	InterleukinsIBA 01/2022 - 06/2017
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022 - 01/2021
3	Blood Glucose (Blood Sugar)IBA 01/2022 - 04/2013
3	Cholinergic Agents (Cholinergics)IBA 01/2022 - 12/2002
3	AntibodiesIBA 01/2022 - 06/2017
3	Neuroprotective AgentsIBA 01/2022 - 04/2012
3	arginine deiminaseIBA 02/2020 - 05/2012
3	pranlukastIBA 01/2017 - 02/2013
3	LipidsIBA 01/2017 - 02/2013
3	montelukast (Singulair)FDA Link 12/2016 - 04/2014
3	Glucose (Dextrose)FDA LinkGeneric 08/2016 - 11/2013
3	Antineoplastic Agents (Antineoplastics)IBA 01/2015 - 11/2012
3	PlatinumIBA 01/2015 - 11/2012
2	Indicators and Reagents (Reagents)IBA 05/2022 - 06/2009
2	p38 Mitogen-Activated Protein KinasesIBA 05/2022 - 01/2022
2	ursodoxicoltaurineIBA 05/2022 - 07/2019
2	Messenger RNA (mRNA)IBA 02/2022 - 04/2021
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2022 - 10/2018
2	Long Noncoding RNAIBA 01/2022 - 10/2021
2	CholesterolIBA 01/2022 - 05/2017
2	Therapeutic UsesIBA 01/2022 - 12/2019
2	6alpha-ethyl-23(S)-methylcholic acidIBA 01/2022 - 10/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 03/2019
2	CateninsIBA 01/2022 - 05/2020
2	RNA (Ribonucleic Acid)IBA 12/2021 - 01/2020
2	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 12/2014
2	AutoantibodiesIBA 11/2021 - 01/2021
2	ClusterinIBA 10/2021 - 04/2021
2	CopperIBA 07/2021 - 11/2012
2	xihuangIBA 04/2021 - 01/2021
2	Biological ProductsIBA 01/2021 - 12/2016
2	Cell-Free Nucleic AcidsIBA 04/2020 - 01/2019
2	Immunoglobulin G (IgG)IBA 01/2020 - 06/2017
2	zileuton (Zyflo)FDA Link 01/2020 - 01/2018
2	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2020 - 01/2018
2	Calcium Channels (Calcium Channel)IBA 12/2019 - 01/2019
2	InterferonsIBA 12/2019 - 06/2017
2	CalciumIBA 12/2019 - 01/2019
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2019 - 12/2016
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 06/2017
2	Glutamine (L-Glutamine)FDA Link 01/2017 - 11/2013
2	Cisplatin (Platino)FDA LinkGeneric 12/2016 - 11/2012
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2015 - 08/2012

Therapy/Procedure

11	Therapeutics 12/2019 - 05/2012
5	Drug Therapy (Chemotherapy) 09/2018 - 11/2012
3	Cesarean Section (Caesarean Section) 03/2022 - 12/2007
3	Oral Administration 12/2019 - 01/2014
2	Liver Transplantation 04/2020 - 01/2019
2	Transplantation 01/2020 - 06/2005